Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.
نویسندگان
چکیده
The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 2 شماره
صفحات -
تاریخ انتشار 2006